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| Discovery and development of new and potent anticancer agents, antifungal agents, anti-inflammatory agents are the major research interests in Professor Ojima's laboratory. Integration of all relevant chemistry and biological tools, including computational biology (docking, in silico screening, molecular dynamics), chemical biology (protein expression, enzyme assays, fluorescence labeling), cell biology (cell culture, cytotoxicity assay, fluorescent confocal microscopy, flow cytometry, transmission and scanning electron microscopy), has successfully been realized in this program. Naturally, this research program is promoted in close collaboration with cell biologists, oncologists, microbiologist, pharmacologists, hematologists, toxicologists, etc., as well as the Division of Laboratory Animals Resources for in vivo efficacy evaluations. The Ojima Laboratory has also been exploring and developing new synthetic methodologies, especially based on catalytic organic transformations, including enantioselective processes, cyclohydrocarbonylations and higher order cycloadditions and carbocyclizations, which provide the basis for the efficient syntheses of biologically active substances of medicinal interest. |
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News
Congratulations to our Simon's Summer Research students on their completion of the program!
Congratulations to Dr. Kalani Jayanetti for successfully defending her thesis!
Welcome to our Simon's Summer Research students Katie Shou, Allyson Wong and Elizabeth Xiu!
Research
Antinociception via FABP5 Inhibition
Anticancer Effects of FABP Inhibitors
Novel Antifungal Acylhydrazones
Inhibition of Steryglucosidases
Next Generation Taxoids
Tumor-Targeting Drug Delivery
Prof. Ojima
"Quest for Scientific Excitement at the Multidisciplinary Interface of Chemistry, Biology and Medicine."
